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GLP-1 receptor agonists (RA), such as Ozempic and Mounjaro, were initially designed to help manage blood sugar in type 2 diabetes

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Impaired intestinal afferent nerve satiety signalling and vagal afferent excitability in diet induced obesity in the mouse

Additionally, most of the articles assessed disagreed on many points related to study results which led to differences in interpretations of recommendations

2,48 Concern about the risk of pancreatitis increased after GLP-1 receptor agonist indications for use expanded to include cardiovascular and renal protection, obesity and metabolic dysfunctionassociated fatty liver disease (MAFLD