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With the medications known to reduce muscle mass, Whyte said an important question was whether this went beyond what would be expected from weight loss alone

The table below shows how many weeks you should stop the medicine before planning a pregnancy for some GLP-1 agonists

The only FDA-approved oral GLP 1 receptor agonist is oral semaglutide, branded as Rybelsus

adults were interested in the use of these drugs for weight management, this number declined to 14% when they were informed about gaining the weight back after discontinuing therapy.

Gastroenterology (2012) 142:71125.e6

The phase 3 REDEFINE 1 trial expanded on these findings dramatically