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Found Health's website references clinical trial data showing that in a 68-week trial studying Wegovy (semaglutide 2.4 mg), the average weight loss was approximately 15% when paired with diet and exercise changes

That also could potentially undo any metabolic improvements that can go hand-in-hand with weight loss, such as in diabetes and blood pressure
Belani A, Kresovi A, Troskot Dijan M (2021) Glucagon-like peptide-1 receptor agonists in the era of COVID -19: Friend or foe
Hall, A

, Poon, T
Over-exercising can overstress your hormonal system