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The Need for Effective Weight Loss Medication I recently saw a headline arguing that GLP-1 agonists are an even more revolutionary advance than certain aspects of artificial intelligence

Semaglutide may cause night sweats due to its impact on glucose metabolism, which can lead to fluctuations in blood sugar levels

doi: 10.1016/j.metabol.2021.154712 [DOI] [PubMed] [Google Scholar] 28

These data suggested that berberine ameliorates diabetic conditions in db/db mice

Danuglipron (PF-06882961) in type 2 diabetes: a randomized, placebo-controlled, multiple ascending-dose phase 1 trial

Including these benefits in the microsimulation model would have made the GLP-1 drugs look a bit more cost-effective
