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N Engl J Med 369:13171326 Meier JJ (2012) GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus

A peer-reviewed 2026 review mapped the pediatric GLP-1 trial data

In addition to its effects on insulin, GIP plays a crucial role in fat accumulation by promoting the activity of adipocyte-expressed lipoprotein lipase and promoting bone formation by preventing osteoclast apoptosis, as evidenced by the thinner bone trabeculae seen in mice lacking GIP receptors [2022]

[DOI] [PMC free article] [PubMed] [Google Scholar] 150.Tashiro Y., Sato K., Watanabe T., Nohtomi K., Terasaki M., Nagashima M

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The intravenous route was chosen for administration of the parenteral control since this would ensure greatest reproducibility of entry into the bloodstream, and would match more closely the time course of entry of peptide from the intestine, which is seen to be rapid