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Published Phase 2 data (Jastreboff et al., NEJM 2023, N=338) demonstrated that Retatrutide at 12mg achieved 24.2% mean body weight reduction at 48 weeks surpassing Tirzepatides 22.5% achieved in 24 additional weeks
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The magnitude of these changes is noteworthy: A reduction of 4.83 mmHg in systolic blood pressure A decrease of 2.45 mmHg in diastolic blood pressure Consistent effects even at higher doses Perhaps most striking is the medication's impact on patients' need for blood pressure medications
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