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Semaglutide works by activating GLP-1 receptors, which helps decrease appetite and overall calorie intake, making it highly effective for weight loss and glycemic control when used consistently

14,15 Potential Direct Effects on the Heart Although the systemic indirect effects of GLP-1RAs are well established as the primary drivers of their clinical benefit in HF, emerging preclinical and mechanistic evidence suggests GLP-1RAs may also exert some direct cardioprotective effects, as discussed below

Summary of revisions: Standards of Care in Diabetes 2026

Image Credit: Reshetnikov_art / Shutterstock.com Diabetes management during pregnancy The increased incidence of type 2 diabetes mellitus (T2DM) and increasing maternal age worldwide have led to higher use of insulin, as well as second-line anti-diabetic medications (ADM) during pregnancy
