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Multiple meta-analyses further revealed this complexity: A meta-analysis on the body component modification effect of GLP-1 receptor agonists showed that compared with the control group, GLP-1RA users not only had a significant reduction in fat body mass, but also a more obvious reduction in lean body mass (weighted mean difference was 1.02 kg) [55]

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However, some general side effects from tirzepatide and semaglutide include but are not limited too: Nausea Vomiting Stomach issues Difficulty going to the bathroom Heartburn Reaction around the injection site Fatigue With semaglutide injections, B12 complex can be added to the medication to ease certain side effects as your body adjusts to the medication