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For most patients, this resolves as the body adapts to the new hormonal environment

Its difficult to distinguish direct anti-inflammatory effects from the benefits of weight loss and improved metabolic health, but the pattern is consistent enough to warrant further study. A 2025 study found that RA patients with a BMI over 27 taking GLP-1 medications showed improvements in symptoms and disease activity

These options will be discussed hereafter based on a selective literature search and are summarized in Fig

Complete clearance typically takes four to six weeks, though individual metabolism varies

PlexusDx offers compounded tirzepatide injection starting at $249 per month as an alternative GLP-1 option with a different structure

General and Comparative Endocrinology, 270, 7581