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It's a solvable problem

If gastrointestinal symptoms are problematic, your provider may recommend delaying dose increases, temporarily reducing your dose, or holding treatment briefly while symptoms improve

Side Effects Semaglutide and Tirzepatide can cause side effects such as nausea, diarrhea , and other gastrointestinal issues

This indicates that DA-CH5 has a greater comprehensive advantage and more optimal target sites, making it more likely to be used clinically in the future compared to DA-JC4 and DA-JC1

Once-daily oral semaglutide (Rybelsus) achieves an HbA 1c reduction of around 1115 mmol/mol in people with type 2 diabetes less than injectable semaglutide but comparable to other long-acting injectable GLP-1 RAs

The drug was already approved earlier this year for obesity and overweight with related conditions, effectively expanding the company's total addressable market with the addition of an oral alternative to injectable GLP-1 drugs.
