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While clinical reports document allodynia as an adverse effect, a parallel body of research shows that GLP-1 receptor agonists, including semaglutide, possess significant anti-pain and neuroprotective properties

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Staying on with the treatment over the long-term helps maintain these changes

An oral GLP-1 receptor agonist works the same way as the injectable version

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These medications help override these adaptations while active, but their protective effect ends with discontinuation