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Lusk, MD, MBA , preventive medicine resident at University of North Carolina-Chapel Hill and visiting research scholar at Duke University, and colleagues projected the fiscal impact of tirzepatide if it were prescribed for all U.S

Managing the start of both medications Timing the start of each medication thoughtfully can make the combination smoother

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Emerging medications and the expanding toolbox The field is evolving rapidly

The substantial weight reduction observed with tirzepatide monotherapy (15-21% body weight in clinical trials) suggests that any perceived benefits likely reflect tirzepatide's pharmacological effects rather than synergistic action

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