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Gradual tapering over 48 weeks significantly reduces this rebound by allowing hunger hormones to normalize progressively rather than spiking suddenly

Tsutsumi, Y., Nomiyama, T., Kawanami, T., Hamaguchi, Y., Terawaki, Y., Tanaka, T., Murase, K., Motonaga, R., Tanabe, M., & Yanase, T

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Semaglutide improved outcomes in both the heart failure with reduced EF group (MACE HR 0.65) and the heart failure with preserved EF group (MACE HR 0.69)