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These effects are thought to result from combined modulation of hypothalamic appetite-regulating pathways and mesolimbic reward circuits, as shown in studies using pharmacological antagonists and viral knockdown techniques targeting GLP-1Rs

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The Wegovy injection STEP-1 trial showed average loss of around 17% over 68 weeks, with the newer 7.2mg dose achieving 21% over 72 weeks

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Tirzepatide compared to semaglutide already showed that dual-receptor agonism outperforms single-receptor activation

SGLT2 inhibition eliminates senescent cells and alleviates pathological aging