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Upon infusion, GLP-1 exerts potent vasodilatory effects on conduit artery and arterioles in healthy humans leading to increased blood flow for enhanced microvascular recruitment and muscular perfusion 46

In studies evaluating combined pharmacologic and lifestyle interventions, patients receiving both GLP-1 therapy and structured nutrition guidance achieved greater weight loss, better adherence, and were more likely to sustain weight loss after discontinuing medication compared to those receiving pharmacotherapy alone (Wadden et al., 2021

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Diabetes Obes Metab 2017;19:1233-41.PubMed 59

The SURPASS-1 trial investigated the efficacy and safety of the three doses of 5, 10, or 15 mg tirzepatide in drug-nave patients with T2D who were not sufficiently controlled with a lifestyle intervention with diet and exercise versus placebo (70)

The switching from tirzepatide to semaglutide dosage chart outlines specific protocols for this direction