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Reduced amounts of IL-10, which is produced by lymphocytes and macrophages, are associated with metabolic syndrome and inflammatory responses in individuals with T2D via the reduction of tyrosine kinase activity of insulin receptors [27]
Despite normalization of liver injury indices is an independent predictor of fibrosis improvement in patients with NASH [65], for several drugs this improvement is not associated with a significant histological and prognostic benefit [7,68]
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