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Reduced outdoor activity: Weeks coinciding with January-March may show slightly slower progress if outdoor exercise is primary activity

Generalized dermatitis due to oral ephedrine

Following the discovery of insulin, the Belgian physiologist La Barre demonstrated that duodenal extracts stimulate insulin secretion and termed these gut-derived hormones incretins 10,11

This multi-receptor approach is a focus of ongoing clinical investigation

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The tirzepatide experience provided proof of concept that combining receptor targets could enhance weight loss without proportionally increasing adverse events