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Some patients may have asymptomatic gallstones discovered incidentally on imaging performed for other reasons

In pancreatic -cells, PC2 cleaves proglucagon to yield mature glucagon (29 aa), glicentin-related pancreatic polypeptide (GRPP) and the major proglucagon fragment (MPGF)

doi: 10.1016/j.medidd.2024.100188

However, some research suggests MOTS-C may have differential efficacy between sexes, with some evidence indicating men may experience more pronounced metabolic effects

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