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Fatigue is listed as a common adverse reaction (occurring in 5% of patients) in the FDA prescribing information for both Wegovy (semaglutide 2.4 mg) and Zepbound (tirzepatide), and occurred more frequently than with placebo in clinical trials

Payers are closely monitoring utilization trends because GLP-1 prescriptions have surged globally

, Hansson, C

Nature Reviews Neuroscience, 18(12), 741752

These can make it difficult to eat enough, especially protein, and maintain proper nutrition
