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Common side effects shared by both medications: Nausea (most common, usually transient peaks during dose escalation) Vomiting Diarrhea or constipation Decreased appetite and early satiety Bloating or stomach discomfort Injection site reactions Key safety warnings that apply to both drugs: FDA Boxed Warning (both): Possible risk of thyroid C-cell tumors, based on animal studies

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These are most common during initiation and dose escalation

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These effects were observed early and were sustained with longer duration of treatment

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Fusaroli M, Salvo F, Begaud B, AlShammari TM, Bate A, Battini V, Brueckner A, Candore G, Carnovale C, Crisafulli S, Cutroneo PM, Dolladille C, Drici MD, Faillie JL, Goldman A, Hauben M, Herdeiro MT, Mahaux O, Manlik K, Montastruc F, Noguchi Y, Noren GN, Noseda R, Onakpoya IJ, Pariente A, Poluzzi E, Salem M, Sartori D, Trinh N, Tuccori M, van Hunsel F, van Puijenbroek E, Raschi E, Khouri C

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Shortages of tirzepatide, sold as a diabetes drug (Mounjaro) and a weight-loss medication (Zepbound), have fueled demand for compounding pharmacies to make their own versions of the medicine, which patients say are cheaper and easier to get

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