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Starting at a lower retatrutide dose and increasing every four weeks gives GI adaptation time to occur as glucagon receptor tone adjusts, reducing nausea, vomiting, and diarrhea during induction

Someone tapering from 10 mg needs less time than someone tapering from 15 mg

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Efficacy and safety Beyond its primary use for type 2 diabetes, tirzepatide has been explored for its potential in treating obesity, osteoarthritis of the knee, atherosclerosis, and other metabolic diseases

The most commonly reported adverse events (observed in 5% of clinical trial participants) were nausea, diarrhea, vomiting, constipation, abdominal pain, dyspepsia, injection-site reactions, fatigue, hypersensitivity reactions, eructation, hair loss and gastroesophageal reflux disease