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These include: Nausea (the most frequently reported adverse effect) Vomiting Diarrhoea Constipation Decreased appetite (which, while contributing to weight loss, can occasionally be excessive) These effects were generally mild to moderate in severity and occurred most frequently during the dose-escalation phase

Autosomal recessive PKD is when both parents have to pass on the recessive or inactive genes to the child

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Certain individuals should not advance to the highest doses or may require slower titration: people with a personal or family history of medullary thyroid cancer, those with severe pancreatitis, and individuals with diabetic retinopathy or kidney disease

Fatigue from Semaglutide is a common early side effect