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Key results The results were dose-dependent and remarkable at every level: 1mg: Approximately 8.7% weight loss 4mg: Approximately 17.1% weight loss 8mg: Approximately 22.8% weight loss 12mg: Approximately 24.2% weight loss Placebo: Approximately 2.1% weight loss The 24.2% weight loss at 12mg over 48 weeks was unprecedented

At first glucagon attracted little attention and it was not thought to have any bearing on disease

Enhanced blood sugar control in type 2 diabetes, via both incretin pathways

The neuroprotective-panacea framing was too large for a class whose two definitive neurodegeneration trials have now read out negative

The impact of hemodialysis on dapagliflozin exposure is not known [see DOSAGE AND ADMINISTRATION , WARNINGS AND PRECAUTIONS , Use In Specific Populations and Clinical Studies ]
