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Several studies show that metformin can increase plasma active GLP-1 level through enhancing GLP-1 secretion from intestinal L cells 21 or inhibiting dipeptidyl peptidase 4-mediated GLP-1 degradation 22,23

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Emerging evidence suggests additional therapeutic benefits in chronic kidney disease, fatty liver disease, obstructive sleep apnoea, addiction, neuroinflammation, and neurodegenerative disorders [7]

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