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This heterogeneity and poorly understood neurobiology pose significant challenges to existing drug development paradigms, resulting in scarce treatment options, especially for bipolar depression

Do not combine semaglutide (Ozempic) with sitagliptin (Januvia) in the same patient

Attach the needle: Remove the plastic tab from the pen cap
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Semaglutide may help lower cholesterol indirectly through weight loss and metabolic improvements, but direct lipid-lowering effects remain modest

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