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Weight Management Module for Perimenopausal Women: A Practical Guide for Gynecologists. Journal of Mid-Life Health , vol

Some practitioners start with semaglutide (more data) and switch to tirzepatide (broader mechanism) if response is insufficient

The GLP-1 receptor is a type of cell surface receptor that binds to GLP-1, triggering a signaling cascade that leads to various effects, including the stimulation of insulin secretion, the inhibition of gastric emptying, and the promotion of satiety

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Isl1 also interacts with the enhancer region of the genes encoding for insulin [124] and somatostatin [125], stimulating their transcription