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Long-chain fatty acids and their derivatives specifically activate multiple types of GPCRs including, GPR119, GPR120, and GPR40 (96), and this activation also stimulates GLP-1 secretion

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It acts through the GLP-1 receptor (GLP-1R), a G protein-coupled receptor (GPCR) predominantly expressed in pancreatic -cells, the gastrointestinal tract, and the central nervous system

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Wang sees no signs of this regulatory momentum slowing down

Accordingly, HIF-1 accumulation was also abrogated upon PI3K/mTOR inhibition, further demonstrating its importance for the observed metabolic adaptations (Fig