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Description
Our results reveal the existence of residue networks crucial for unimolecular agonist-mediated receptor activation and their distinct signaling patterns, which might be useful to the rational design of biased drug leads.

Jacqueline Maya,

Originally developed to treat type 2 diabetes (T2D), these drugs have since delivered major advances in managing obesity and cardiovascular risk reduction
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Triple agonist (GLP-1/GIP/Glucagon), under clinical investigation