does glp-1 actually work receptor agonists GLP-1 Drugs for Weight Loss

The pharmaceutical reason is straightforward: peptides are large protein molecules that require sufficient concentration to activate their target receptors on nerve cells and organs

At $11$14 per meal, that's $33$42 wasted in a single week

Thus, a deficiency of GLP-1 is now considered as part of the pathophysiology of type 2 diabetes 1

No, there is no specific antidote for semaglutide overdose

Consequently, this promotes fundic relaxation, decreases peristalsis in the gastric antrum and duodenum, and increases pyloric sphincter tone, thereby delaying the transfer of gastric contents into the duodenum [29]

Obesity Atlas 2023