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Serious concerns like pancreatic or thyroid cancer remain unconfirmed due to their rarity.[6] While the risk of hypoglycemia is generally low, it increases when combined with insulin or sulfonylureas.[2] Upper respiratory infections were reported in several trials, particularly with oral semaglutide, though the mechanism remains unclear

Moreover, the levels of Pan-Kla, H3K18la and H4K12la were markedly increased in TGF-1 + IL-1-treated fibroblasts, while H4K5la remained unchanged (Fig