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Retrieved from Wang, W., Wang, Q., Qi, X., et al

Ann Intern Med 2009;150:604612 [DOI] [PMC free article] [PubMed] [Google Scholar] 15

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SELECT trial demonstrated CV event reduction in obesity without diabetes the first obesity drug with a proven MACE outcome

The biological drive overwhelms the behavioral changes

Leptin receptor neurons in the dorsomedial hypothalamus require distinct neuronal subsets for thermogenesis and weight loss
