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Circulation 107(25):31333140

Ongoing coaching: Patients receive help to stick to changes over the long term

Effects on Body Fat Over time, consistent regulation of blood sugar and appetite through GLP-1 activity may lead to a reduction in overall body fat percentage, particularly visceral fat, which is linked to metabolic diseases

However, after the SELECT trial showed 20% MACE reduction, CMS issued guidance in March 2024 allowing Part D coverage of Wegovy specifically for cardiovascular risk reduction in patients with established CVD and a BMI of 27 or higher

MarketScan data shows that only 66% of continuously enrolled new GLP-1 patients were persistent on Obesity medications for at least 40 weeks (10 months) in 2022 2024, compared to 77% of patients taking Diabetes products

Landmark clinical trials, such as the STEP programme for semaglutide published in The New England Journal of Medicine, have demonstrated that these medications can lead to average weight loss of 15% or more when combined with lifestyle changes, a level of efficacy previously achievable only through bariatric surgery