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Despite advancements in pharmacotherapy, lifestyle interventions including dietary modifications, physical activity, and behavioral counseling remain the foundation of effective and sustainable obesity management, emphasizing the need for a holistic, patient-centered approach to long-term weight control

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Prebiotic fiber: the microbiome feeders Prebiotic fibers are a specific subset of fibers, usually soluble and fermentable, that selectively feed beneficial gut bacteria

We set it as an absolute difference of 0.1% between groups, which is more conservative than the difference found in previous trials 20

GLP-1 receptor agonists (GLP-1RAs) are designed to mimic the action of endogenous GLP-1 but have a longer duration of action, making them effective therapeutic agents for type 2 diabetes [40]