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In 2021, Novo Nordiskwhich also markets the GLP-1 receptor agonist semaglutide as Rybelsus for T2Dlaunched two Phase III trials, EVOKE and EVOKE Plus, studying the drug in approximately 3,700 people with early-stage Alzheimers disease

The disease is characterized by progressive glandular hypoplasia, invasion of the affected lacrimal and salivary glands by CD4 + T cells, along the existence of anti-Ro/SSA antibodies in the serum [275, 276]