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Thank U Eric, this is very important new data

HS is a solely human disease and genetic mouse models, such as those with altered Notch signaling pathways, have shown multiple limitations, including the lack of altered immune responses and destructive tunnel-forming nature typically observed in human HS [64]

The key principle is separation: levothyroxine should be taken on an empty stomach, ideally 30 to 60 minutes before eating or taking other medications

Which has relatedness as one of its factors, how does that factor into this

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Wait at least 2-3 hours before lying down