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difference from placebo for combination therapy: 3% [95% CI 6%, 1%], p =0.02)

This is achieved by inhibiting the protein PTEN and activating the PI3K/AKT/mTOR and PI3K/AKT/GSK3 pathways, as well as preventing the movement of vascular smooth muscle cells (Figure 2) (32, 33)

Accessing it outside of a clinical trial requires investigational pathways or compounded formulations, which carry different regulatory considerations

It interferes with nutrition

Patients were randomized to 4 mg, 9 mg, or 12 mg of retatrutide, or placebo

In clinical trials, retatrutide has been given as a weekly injection under the skin (subcutaneous)