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GLP-1R works through the combination of the endogenous ligand Glucagon-like peptide-1 (GLP-1) or exogenous agonists, which activate multiple intracellular signaling pathways that enhance insulin secretion, inhibit glucagon secretion, protect -cells from apoptosis, delay gastric emptying and increase satiety

Cai X, Gao X, Yang W, et al

Although the quality of the evidence was low, limited by small numbers and a short duration of therapy (mostly less than 12 weeks), the improvement in disease activity and quality of life scores is compelling

Knowing what to expect can help you manage any side effects and know when to seek medical advice if needed

Prescribers can decide to use a medication off-label because, in their professional judgment, they believe it may offer a benefit to someone

Your provider orders a comprehensive panel, interprets the results, and uses them to personalize your plan