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This very short action limited the initial enthusiasm for the possible usefulness of incretins for the treatment of T2DM, and in turn stimulated the development of both GLP1 agonists resistant to DPP-4, with a longer half-life and of DPP-4 inhibitors that prolong the half-life of native incretins

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Traditional GLP-1 receptor agonists, such as semaglutide, primarily promote weight loss by suppressing appetite, slowing gastric emptying, and improving insulin secretion

Unlike semaglutide which solely activates GLP-1R (one of the three pivotal receptors regulating glucose homeostasis), tirzepatide also activates glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) to enhance metabolic benefits with reduced side-effects 5

These high-purity, in vivo-ready reagents are ideal for preclinical research in metabolic, cardiovascular, and neuroprotective investigations