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Although it is a good source of fibre and helps feed gut bugs, it ferments within the gut and can cause a lot of gut issues like extreme gas, cramping and bloating

Whether the discrepancy in results of these studies is due to the use of native GLP-1 vs

Genetic factors, including variants in your GLP1R and GIPR genes, influence how strongly your body responds to dose increases

Rybelsus can also be kind of a chore to take, because it works best when patients fast overnight beforehand and then only drink a few small sips of water for the first 30 minutes afterward

Lancet Diabetes Endocrinol 3(5):367381 van Bommel EJM, Muskiet MHA, Tonneijck L, Kramer MHH, Nieuwdorp M, van Raalte DH (2017) SGLT2 inhibition in the diabetic kidneyfrom mechanisms to clinical outcome

However, muscle mass does not appear to recover when the drug is stopped and is of potential concern especially for older patients though its impact on overall health is unclear (1)