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The European Medicines Agency (EMA) has recommended updating the product information for these medicines to include NAION as a side effect, with a frequency classified as very rare.Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), is the active ingredient in medications used to treat type 2 diabetes and obesity

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It was approved for seasonal influenza by US Food and Drug Administration in 1999, and approval from Japanese agencies and the European Medicines Agency (EMA) followed soon afterwards.

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