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doi: 10.1038/s41392-022-01149-x
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The Safety, Tolerability and Efficacy of Rapid UpTitration of GuidelineDirected Medical Therapies in Acute Heart Failure (STRONG-HF) trial validated rapid up-titration strategies, demonstrating that early high-intensity GDMT implementation with structured follow-up significantly reduces 180-day mortality and readmissions
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