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Like many Americans each January, my spouse and I decided to lose some excess pounds this year.

After a 4-week run-in period in which participants were treated with diet and exercise alone, those who fulfilled the randomisation criteria were randomised (1:1:1:1) using a web-based randomisation system to receive once-daily oral semaglutide 3 mg, 7 mg or 14 mg or placebo for 26 weeks (using a 4-week dose-escalation regimen for the higher doses)

Together, these medications act on the brains hunger and reward centers, making it easier to manage portions, resist cravings, and stay consistent with lifestyle changes.

Game-changing oral drug has similar success rate to injections with potentially serious side-effects

Mix 3 tablespoons of powder into 8 ounces of water or liquid

Discover what UK clinical evidence says about sleep disturbances with semaglutide, potential contributing factors, and when to seek medical advice about unusual dreams during weight management treatment.