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Published large human clinical-trial data is not available, so a regulator-grade answer to that question does not exist

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who found that intervertebral discs away from the fracture sides did not develop any MRI signal changes after 1 year

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Increased liver enzyme levels were observed in clinical trials, raising concern for hepatotoxicity with long-term use of SARMs Narayanan et al., Therapeutic Advances in Endocrinology and Metabolism 3

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