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Conclusions Our study identified genetic proxies of GLP-1R-based agonists and demonstrated their causal effects on reducing the risk of MASLD and complications including liver cancer and CVD, probably by improving hyperlipidemia and insulin resistance and partly independent of the weight-loss effect

The benefits of Wegovy and Zepbound -like powerful appetite regulation and improved metabolic function-are temporary once the medication is stopped

The expanding role of GLP-1 receptor agonists

Furthermore, we used a spectroscopic assay to determine the stored TAGs (Supplementary Fig

For safe administration, rotate injection sites between areas like the abdomen, thighs, or arms and avoid injecting in the same body region for two consecutive doses

Metformin attenuates production of nitric oxide in response to lipopolysaccharide by inhibiting MyD88-independent pathway