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mibavademab, a leptin receptor agonist (NCT06373146)

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Elevated HbA1c, insulin resistance, and inflammatory markers often indicate longer therapy may support deeper metabolic improvement

Most doctors will have patients start with low doses to reduce any potential GI side effects, then increase the dose based on their response and tolerance

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So realistically, we are looking at 2027 at the earliest before retatrutide could be commercially available in Australia, and that assumes everything goes smoothly