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Medical guidelines suggest limiting alcohol to no more than one drink per day for women and two per day for men when not on GLP-1 therapy

Although direct clinical evidence linking GIPR polymorphisms to tirzepatide response is currently lacking, existing studies suggest a mechanistic rationale in which rs2287019, rs10423928, and other GIPR variants could potentially influence tirzepatide efficacy by altering insulin secretion and glucose homeostasis [37,38]

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However, long-term safety beyond 4868 weeks isn't yet established

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Reyes-Garca R, Moreno-Prez O, Bellido-Castaeda V, Botana Lpez M, Rodrguez-Hervada AD, Fernndez-Garca D