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When GLP-1 levels are low, hunger signals are high

Lower Risk of MACE and All-Cause Death in Patients Initiated on Semaglutide 2.4 mg in Routine Clinical Care: Results from the SCORE Study (Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity in the Real World)

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Yoo SK, et al

For those starting from a low baseline, a gradual increase is advisable to prevent bloating, gas, and abdominal discomfort
