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GLP-1 receptor agonists work by mimicking this endogenous hormone , binding to GLP-1 receptors found throughout the body, particularly in the pancreas, brain, and gastrointestinal tract

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These include: Nausea and vomiting Diarrhoea Reduced appetite and fluid intake These effects can lead to inadequate hydration and depletion of essential electrolytes such as sodium, potassium, magnesium, and calciumall of which are crucial for normal muscle function

Protein-energy malnutrition, micronutrient deficiencies (particularly vitamin C, zinc, and copper), and inadequate hydration can all compromise skin integrity during periods of rapid weight change