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Thyroid Monitoring While on GLP-1 Weight Loss Therapy If you have hypothyroidism and start semaglutide, your TSH (thyroid-stimulating hormone) and free T4 levels should be checked 48 weeks after beginning or adjusting your GLP-1 dose

Published data (SURMOUNT-4 trial) show most patients regain a meaningful portion of lost weight after discontinuation

Abstract Introduction Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are effective for glycemic control, with many also demonstrating cardiovascular (CV) benefit, in people with type 2 diabetes (T2D)

While we anticipate retatrutide being a strong option for many people seeking weight loss, it may be particularly useful for anyone who falls into one or more of these categories: Didnt respond to earlier GLP-1 drugs like Wegovy, Ozempic, Rybelsus, Liraglutide, Zepbound, Mounjaro, etc Plateaued with other GLP-1s but still havent met your target weight Have a large body percentage of weight to lose (20% or more) Retatrutide is currently undergoing clinical trials necessary for it to obtain FDA approval (which is anticipated by summer) , so it's not yet available to be prescribed

Indirect effects of GLP-1 include decreasing hepatic gluconeogenesis and increasing neuroprotection in the liver and brain

Due to its significant weight loss effects, tirzepatide has also shown potential in managing conditions like non-alcoholic fatty liver disease (NAFLD), though further research is necessary (43)(46)