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GPX4 then uses GSH to reduce lipid hydroperoxides to lipid alcohols, thereby suppressing ferroptosis [53]

Further validation arises from ex vivo assessments, revealing curcumins proficiency in curbing RGC loss through the suppression of MAPK, caspase-9, and caspase-3 pathways in murine optic nerves [460]

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Cancer Cell 41 , 10481060.e1049 (2023)

Of course, it is unwise to directly compare the doses given to animals and the doses given to humans, as the bodys surface area should also be taken into account when translating doses between species

doi: 10.1039/D3MH01511D, PMID: [DOI] [PubMed] [Google Scholar] 175.Alrashdan MS, Park JC, Sung MA, Yoo SB, Jahng JW, Lee TH, et al